The 99% Solution

In over 99% of patients, a medicine works as it should. But in less than 1%, the drug causes serious harm. Researchers at The Hamner Institutes and UNC Chapel Hill are collaborating to find out not just why, but how to protect that small group of people from harm. Doing so is part of a growing trend in the pharmaceutical industry called personalized medicine. Get a tour of the lab while diving deep into this issue.

NGSS Performance Expectation: Evaluate a solution to a complex real-world problem based on prioritized criteria and trade-offs that account for a range of constraints, including cost, safety, reliability, and aesthetics as well as possible social, cultural, and environmental impacts.

Discussion Questions

Use the web and links below to answer these questions before you watch the video:

  1. What is a medicine and how does it work?
  2. How do drugs fight infection?
  3. How do drugs treat cancer?
  4. How do drugs replace deficiencies?
  5. How do drugs change how cells work?
  6. What is personalized medicine?

Watch the video to answer these questions:

  1. What is the central question Dr. Watkins is trying to answer in this video?
  2. What is Joe Trask looking for when he used florescent dyes to highlight different parts of the cell?
  3. What is Dr. Merrie Mosedale looking for with her graphs of gene variants?
  4. What makes personalizing medicines complicated?
  5. How do drug companies benefit by the research done at The Hamner Institutes?



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